Cuttlebone extract (Sepia officinalis) exerts its anti-inflammatory effects via suppression of the NF-κB signaling pathway

Document Type : Original papers

Authors

1 Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528, Egypt.

2 Department of Zoology, Faculty of Science, South Valley University, Qena, Egypt.

3 Biochemistry department faculty of veterinary medicine South Valley University

Abstract

Cuttlebone extracts or powder is an old traditional medicine which can be used as antacid in gastric diseases, enhances skin wound healing via enhancing cell migration, reducing serum phosphorus levels, bone repair, has antimicrobial properties and it is beneficial in dental material enhancement. Herein we confirmed the promise of CB in biomedical fields especially its action as an anti-inflammatory natural agent. After induction of burns in diabetic guinea pigs and providing CB extract topically and / or orally, the wound started to heal due to its anti-inflammatory properties as we hypothesized that, CB inhibited NF-κB p65 and P50 activation in skin. Therefore, these results suggested that CB exerts its anti-inflammatory effects through the regulation of the NF-κB signaling pathway which then help in burn healing.

Keywords

Main Subjects

Aswan University Journal of Sciences and Technology
Volume 5, Issue 1
March 2025
Pages 197-205

Files

Share

How to cite

Statistics